I had a spider living in one of my bathrooms. One day I noticed a larger spider was creeping up on it and getting ready to eat it, so I intercepted the aggressor with some TP and squashed it. But my spider buddy must have been made that I messed up its web because it went elsewhere after that.

I have killed a few huge spiders in my house, which I now regret. Except for the one that almost jumped on my hand as I removed something from a cabinet, soon after I moved in. That wasn't one of the monsters though, some of them you could hear when they walked they were so large.